Signaling pathways and targets of natural products in psoriasis treatment
نویسندگان
چکیده
Aim: Psoriasis is a common chronic inflammatory skin disorder, which has adverse effects on patients’ quality of life. Natural products exhibit significant therapeutic capacities with small side and might be preferable alternative treatments for patients psoriasis. This study summarizes the signaling pathways potential targets natural their efficacy psoriasis treatment. Methods: The literature this article was acquired from PubMed Web Science, January 2010 to December 2020. keywords searching included “psoriasis” “natural product”, “herbal medicine”, therapy”, “medicinal plant”, herb” or “pharmaceutical plant”. Results: Herbal extracts, compounds, herbal prescriptions could regulate alleviate symptoms, such as T helper 17 (Th17) differentiation, Janus kinase (JAK)/signal transducer activator transcription (STAT), nuclear factor-kappa B (NF-κB), mitogen‑activated protein (MAPK), phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target rapamycin (mTOR), other pathways, are involved in response keratinocyte hyperproliferation. anti-psoriatic effect clinical trials summarized. Conclusions: exerted by targeting multiple providing evidence investigation novel drugs. Further experimental research should performed screen characterize application
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ژورنال
عنوان ژورنال: Exploration of medicine
سال: 2022
ISSN: ['2692-3106']
DOI: https://doi.org/10.37349/emed.2022.00098